Genetic progression and clonal relationship of recurrent premalignant head and neck lesions.

@article{Califano2000GeneticPA,
  title={Genetic progression and clonal relationship of recurrent premalignant head and neck lesions.},
  author={Joseph A. Califano and William H Westra and Glen Meininger and Russell L Corio and Wayne M Koch and David Sidransky},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2000},
  volume={6 2},
  pages={347-52}
}
We constructed a preliminary genetic progression model for head and neck squamous cell carcinoma (HNSC) based on the frequency of genetic alterations in preneoplastic and neoplastic lesions from single biopsy specimens. To firmly establish the temporal order of established genetic events in HNSC, we sampled serial biopsies from five patients with recurrent premalignant lesions at a single anatomic site over a period of time (1 month to 144 months). These lesions were examined by microsatellite… CONTINUE READING

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