Genetic predisposition to cancer — insights from population genetics

  title={Genetic predisposition to cancer — insights from population genetics},
  author={S. Frank},
  journal={Nature Reviews Genetics},
  • S. Frank
  • Published 2004
  • Biology, Medicine
  • Nature Reviews Genetics
  • Individuals differ in their inherited tendency to develop cancer. Major single-gene defects that cause early cancer onset have been known for many years from their inheritance patterns, and inherited defects that have weaker effects on predisposition were also suspected to exist. Recent progress in cancer genetics has identified specific loci that are involved in cancer progression, many of which have key roles in DNA repair, cell-cycle control and cell-death pathways. Those loci, which are… CONTINUE READING
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