Genetic predisposition to cancer — insights from population genetics
@article{Frank2004GeneticPT, title={Genetic predisposition to cancer — insights from population genetics}, author={S. Frank}, journal={Nature Reviews Genetics}, year={2004}, volume={5}, pages={764-772} }
Individuals differ in their inherited tendency to develop cancer. Major single-gene defects that cause early cancer onset have been known for many years from their inheritance patterns, and inherited defects that have weaker effects on predisposition were also suspected to exist. Recent progress in cancer genetics has identified specific loci that are involved in cancer progression, many of which have key roles in DNA repair, cell-cycle control and cell-death pathways. Those loci, which are… CONTINUE READING
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References
SHOWING 1-10 OF 66 REFERENCES
The population genetics of multistage carcinogenesis
- Biology, Medicine
- Proceedings of the Royal Society of London. Series B: Biological Sciences
- 2003
- 36
- PDF
Genetic insights into familial cancers-- update and recent discoveries.
- Biology, Medicine
- Cancer letters
- 2002
- 80
Genetic variation in cancer predisposition: mutational decay of a robust genetic control network.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 2004
- 34
- PDF
Challenges and complexities in estimating both the functional impact and the disease risk associated with the extensive genetic variation in human DNA repair genes.
- Biology, Medicine
- Mutation research
- 2003
- 202
Mutations and Polymorphisms in the familial early‐onset breast cancer (BRCA1) gene
- Biology, Medicine
- Human mutation
- 1996
- 291
Polygenic susceptibility to breast cancer and implications for prevention
- Medicine, Biology
- Nature Genetics
- 2002
- 804
- PDF