Genetic predisposition to breast cancer: a surgical perspective.

  title={Genetic predisposition to breast cancer: a surgical perspective.},
  author={George H. Sakorafas and Adelais G Tsiotou},
  journal={The British journal of surgery},
  volume={87 2},
BACKGROUND Molecular alterations in proto-oncogenes, tumour suppressor genes, and genes that function in DNA damage recognition and repair are considered to be hallmarks of a carcinogenic process, including breast carcinogenesis. METHODS A computer-assisted search of the English literature (Medline database, 1990-1999) was performed, followed by a manual search of the reference list of pertinent articles retrieved. RESULTS Hereditary breast cancer accounts for 5-10 per cent of all breast… CONTINUE READING