Genetic predictors of medically refractory ulcerative colitis.

@article{Haritunians2010GeneticPO,
  title={Genetic predictors of medically refractory ulcerative colitis.},
  author={Talin Haritunians and Kent D. Taylor and Stephan Raoul Targan and Marla J Dubinsky and Andrew F. Ippoliti and Soonil Kwon and Xiuqing Guo and Gil Y. Melmed and Dror Berel and Emebet A. Mengesha and Bruce M. Psaty and Nicole L. Glazer and Eric A. Vasiliauskas and Jerome I. Rotter and Phillip R. Fleshner and Dermot P. B. McGovern},
  journal={Inflammatory bowel diseases},
  year={2010},
  volume={16 11},
  pages={
          1830-40
        }
}
BACKGROUND Acute severe ulcerative colitis (UC) remains a significant clinical challenge and the ability to predict, at an early stage, those individuals at risk of colectomy for medically refractory UC (MR-UC) would be a major clinical advance. The aim of this study was to use a genome-wide association study (GWAS) in a well-characterized cohort of UC patients to identify genetic variation that contributes to MR-UC. METHODS A GWAS comparing 324 MR-UC patients with 537 non-MR-UC patients was… CONTINUE READING
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