Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and oral cavity cancer.

@article{Katoh1999GeneticPO,
  title={Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and oral cavity cancer.},
  author={Takahiko Katoh and Satoshi Kaneko and Kiyotaka Kohshi and Masahiro Munaka and Kazuko Kitagawa and Naoki Kunugita and Kunio Ikemura and Toru Kawamoto},
  journal={International journal of cancer},
  year={1999},
  volume={83 5},
  pages={
          606-9
        }
}
Both genetic and environmental factors are involved in the development of cancer. Oral cavity cancer has been reported to be epidemiologically associated with tobacco and alcohol consumption. We examined genetic polymorphisms of the glutathione-S-transferase (GST) M1/T1, cytochrome P-450 (CYP) 1A1/2E1 and aldehyde dehydrogenase 2 (ALDH2) genes in 92 Japanese patients with oral cavity cancer and 147 unrelated non-cancer Japanese controls. There was a significant association between cigarette… CONTINUE READING
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