Genetic polymorphisms of the uridine diphosphate glucuronosyltransferase 1A7 and colorectal cancer risk in relation to cigarette smoking and alcohol drinking in a Chinese population.

@article{Chen2006GeneticPO,
  title={Genetic polymorphisms of the uridine diphosphate glucuronosyltransferase 1A7 and colorectal cancer risk in relation to cigarette smoking and alcohol drinking in a Chinese population.},
  author={Kun Chen and Mingjuan J Jin and Yimin Zhu and Qinting Jiang and Weiping Yu and Xinyuan Ma and Kaiyan Yao},
  journal={Journal of gastroenterology and hepatology},
  year={2006},
  volume={21 6},
  pages={1036-41}
}
BACKGROUND The impact of uridine diphosphate glucuronosyltransferase 1A7 (UGT1A7) polymorphisms on genetic susceptibility to digestive system cancer has received close attention since the discovery by Guillemette, the polymorphisms of which may alter enzyme activity. To clarify the allele frequency distribution and its association with risk of colorectal cancer, a population-based case-control study was carried out in Chinese population. METHODS A total of 140 patients with colorectal cancer… CONTINUE READING

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