Genetic polymorphisms of the major histocompatibility complex-encoded antigen-processing genes TAP and LMP in sarcoidosis.

@article{Ishihara1996GeneticPO,
  title={Genetic polymorphisms of the major histocompatibility complex-encoded antigen-processing genes TAP and LMP in sarcoidosis.},
  author={Mami Ishihara and Shigeaki Ohno and Nobuhisa Mizuki and Norihiko Yamagata and Takako Ishida and Taeko Naruse and Shoji Kuwata and Hidetoshi Inoko},
  journal={Human immunology},
  year={1996},
  volume={45 2},
  pages={
          105-110
        }
}
Sarcoidosis is a granulomatous disease showing a significant increase in the HLA-DR5, -DR6, and -DR8 associated alleles in Japanese. To investigate whether the class I antigen-processing genes, encoded within the MHC class II region between the HLA-DP and -DQ loci, are involved in determining the susceptibility to sarcoidosis, TAP1, TAP2, and LMP2 alleles were analyzed by the PCR-RFLP method in 85 Japanese patients with sarcoidosis and 91 healthy controls. There were no significant differences… CONTINUE READING
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