Genetic polymorphisms of matrix metalloproteinases and their inhibitors in potentially malignant and malignant lesions of the head and neck

@inproceedings{Chaudhary2009GeneticPO,
  title={Genetic polymorphisms of matrix metalloproteinases and their inhibitors in potentially malignant and malignant lesions of the head and neck},
  author={Ajay Kumar Chaudhary and Mamta K Singh and Alok Chandra Bharti and Kamlesh Asotra and Shanthy Sundaram and Ravi Mehrotra},
  booktitle={Journal of Biomedical Science},
  year={2009}
}
Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that are capable of cleaving all extra cellular matrix (ECM) substrates. Degradation of matrix is a key event in progression, invasion and metastasis of potentially malignant and malignant lesions of the head and neck. It might have an important polymorphic association at the promoter regions of several MMPs such as MMP-1 (-1607 1G/2G), MMP-2 (-1306 C/T), MMP-3 (-1171 5A/6A), MMP-9 (-1562 C/T) and TIMP-2 (-418 G/C or C… CONTINUE READING
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