Genetic polymorphisms of manganese-superoxide dismutase and glutathione-S-transferase in chronic alcoholic pancreatitis.

@article{Osterreicher2007GeneticPO,
  title={Genetic polymorphisms of manganese-superoxide dismutase and glutathione-S-transferase in chronic alcoholic pancreatitis.},
  author={Christoph H Osterreicher and J{\"u}rgen Schultheiss and Markus Wehler and Nadine Homann and Claus Hellerbrand and Beat M. K{\"u}nzli and Helmut Friess and Helmut Karl Seitz and Felix Stickel},
  journal={Mutagenesis},
  year={2007},
  volume={22 5},
  pages={
          305-10
        }
}
Chronic alcohol consumption is a major risk factor for the development of chronic pancreatitis. However, chronic pancreatitis occurs only in a minority of heavy drinkers. This variability may be due to yet unidentified genetic factors. Several enzymes involved in the degradation of reactive oxidants and xenobiotics, such as glutathione-S-transferase P1 (GSTP1) and manganese-superoxide dismutase (MnSOD) reveal functional polymorphisms that affect the antioxidative capacity and may therefore… CONTINUE READING

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