Genetic polymorphisms of interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor {alpha} and risk of gastric cancer in a Chinese population.

@article{Lu2005GeneticPO,
  title={Genetic polymorphisms of interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor \{alpha\} and risk of gastric cancer in a Chinese population.},
  author={Wanli Lu and Kai-feng Pan and Lian Zhang and Dongxin Lin and Xiaoping Miao and Wei-cheng You},
  journal={Carcinogenesis},
  year={2005},
  volume={26 3},
  pages={631-6}
}
Helicobacter pylori infection and the cytokine-mediated inflammatory responses play important roles in gastric cancer pathogenesis. This case control study was conducted to assess the association between genetic polymorphisms in interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor alpha (TNFalpha), which are involved in H.pylori infection, and risk of gastric cancer. Genotypes were determined by PCR-based denaturing high-performance liquid chromatography analysis and direct DNA… CONTINUE READING
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