Genetic polymorphisms of glutathione S-transferases and disease activity of rheumatoid arthritis.

@article{Grabar2009GeneticPO,
  title={Genetic polymorphisms of glutathione S-transferases and disease activity of rheumatoid arthritis.},
  author={Petra Bohanec Grabar and Du{\vs}an Logar and Matjia Tomsic and Bla{\vz} Rozman and Vita Dol{\vz}an},
  journal={Clinical and experimental rheumatology},
  year={2009},
  volume={27 2},
  pages={229-36}
}
OBJECTIVES Glutathione S-transferases (GST); GST-mu1 (GSTM1), GST-pi1 (GSTP1) and GST-theta1 (GSTT1) have peroxidase activity towards cytotoxic metabolites produced in inflammatory reactions, the main feature of rheumatoid arthritis (RA). Genetic polymorphisms in GSTM1, GSTP1 and GSTT1 modify the enzyme conjugation capacity and may be associated with the activity of RA. METHODS A genotyping approach was used to analyze GSTM1-0, GSTT1-0 and GSTP1 Ile105Val and Ala114Val polymorphisms in 213 RA… CONTINUE READING