Genetic polymorphisms of gene conversion within the duplicated human α-globin loci

Abstract

Of the 645 Japanese subjects studied, we have identified 10 individuals heterozygous for a chromosome with the triplicated α-globin loci. The frequency of the triple α-loci was 0.008 in this population, while that of the single α-locus, i.e., α-thalassemia 2 gene, might be lower than 0.0008. Analysis of haplotypes using particular RsaI site polymorphism in the α-globin gene complex strongly suggests that the triple α loci may have had multiple origins in this population.

DOI: 10.1007/BF00210811

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Cite this paper

@article{Nakashima2004GeneticPO, title={Genetic polymorphisms of gene conversion within the duplicated human α-globin loci}, author={Hitoshi Nakashima and Asao Fujiyama and Shunjiro Kagiyama and Takashi Imamura}, journal={Human Genetics}, year={2004}, volume={84}, pages={568-570} }