Genetic polymorphisms of epidermal growth factor in relation to risk of hepatocellular carcinoma: two case-control studies

@inproceedings{Yuan2013GeneticPO,
  title={Genetic polymorphisms of epidermal growth factor in relation to risk of hepatocellular carcinoma: two case-control studies},
  author={Jian-Min Yuan and Yunhua Fan and Simona Ognjanovic and Renwei Wang and David J. Van Den Berg and Sugantha Govindarajan and Mimi C. Yu},
  booktitle={BMC gastroenterology},
  year={2013}
}
BACKGROUND Earlier, we reported a highly statistically significant association between T-helper 1 (Th1) and Th2 cytokine genotypes and hepatocellular carcinoma (HCC) risk among natives of southern Guangxi, China, a hyperendemic region for HCC. Epidermal growth factor (EGF) plays a critical role in malignant transformation of hepatocytes and tumor progression. A polymorphism in the EGF gene (61A > G) results in elevation of EGF in liver tissues and blood. Epidemiological data are sparse on the… CONTINUE READING
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Inflammation in carcinogenesis

  • S Ognjanovic, P Hainaut
  • Edited by Sipes IG,
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