Genetic polymorphisms of drug-metabolizing cytochrome P450 enzymes in cynomolgus and rhesus monkeys and common marmosets in preclinical studies for humans.

Abstract

Cynomolgus monkeys (Macaca fascicularis, Old World Monkeys) and common marmosets (Callithrix jacchus, New World Monkeys) have been widely, and expectedly, used as non-human primate models in drug development studies. Major drug-metabolizing cytochrome P450 (P450) enzymes information is now available that supports these primate species as animal models, and… (More)
DOI: 10.1016/j.bcp.2017.12.015

Cite this paper

@article{Uno2017GeneticPO, title={Genetic polymorphisms of drug-metabolizing cytochrome P450 enzymes in cynomolgus and rhesus monkeys and common marmosets in preclinical studies for humans.}, author={Y Uno and Shotaro Uehara and Hiroshi Yamazaki}, journal={Biochemical pharmacology}, year={2017} }