Genetic polymorphisms of cytochrome P450 and glutathione S-transferase associated with antituberculosis drug-induced hepatotoxicity in Chinese tuberculosis patients.

@article{Wang2010GeneticPO,
  title={Genetic polymorphisms of cytochrome P450 and glutathione S-transferase associated with antituberculosis drug-induced hepatotoxicity in Chinese tuberculosis patients.},
  author={Tian-lin Wang and Hee Tae Yu and Wei Wang and Yan You Pan and Ling T. He and Zhang Yang Wang},
  journal={The Journal of international medical research},
  year={2010},
  volume={38 3},
  pages={977-86}
}
This study was designed to investigate the association of genetic polymorphisms of cytochrome P450 subtype 2E1 (CYP2E1) and glutathione S-transferase mu 1 (GSTM1) with susceptibility to antituberculosis drug-induced hepatotoxicity (ADIH) in Chinese tuberculosis patients. All patients were treated with a combination of isoniazid, rifampicin, pyrazinamide and… CONTINUE READING