Genetic polymorphisms of cytochrome P450 among patients with Balkan endemic nephropathy (BEN).


OBJECTIVES The concept of multifactorial etiology of BEN anticipates that a combination of polymorphic gene variants and various environmental factors causes an increased risk for the disease. CYP enzymes play a key role in the metabolic activation of environmental chemicals and toxins. CYP3A enzymes are particularly relevant for xenobiotic metabolism… (More)


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