Genetic polymorphisms of cytochrome P450 CYP1A1 (*2A) and microsomal epoxide hydrolase gene, interactions with tobacco-users, and susceptibility to bladder cancer: a study from North India

@article{Srivastava2007GeneticPO,
  title={Genetic polymorphisms of cytochrome P450 CYP1A1 (*2A) and microsomal epoxide hydrolase gene, interactions with tobacco-users, and susceptibility to bladder cancer: a study from North India},
  author={Daya Shankar Lal Srivastava and Anil Mandhani and Rama Devi Mittal},
  journal={Archives of Toxicology},
  year={2007},
  volume={82},
  pages={633-639}
}
The role of low penetrance genes and environmental factors in the etiology of bladder cancer (CaB) is unclear, but may involve genetic and environmental factors. Most environmental pro-carcinogens require metabolic activation by phase I enzymes (CYP450s), However, phase II enzyme (i.e., microsomal epoxide hydrolase: mEH) is mainly involved in the detoxification of wide variety of endogenous or exogenous carcinogens. Genetic differences in CYP1A1 gene and the mEH gene polymorphisms have been… CONTINUE READING

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Cancer incidence in Wve continents, vol VII. International Agency for Research on Cancer (IARC)

  • J Young
  • Lyon, ScientiWc Publication
  • 1997
Highly Influential
2 Excerpts

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