Genetic polymorphisms of UDP-glucuronosyltransferases and their functional significance.

@article{Miners2002GeneticPO,
  title={Genetic polymorphisms of UDP-glucuronosyltransferases and their functional significance.},
  author={John O. Miners and Ross A. McKinnon and Peter I. Mackenzie},
  journal={Toxicology},
  year={2002},
  volume={181-182},
  pages={453-6}
}
UDP-Glucuronosyltransferase (UGT), the microsomal enzyme responsible for glucuronidation reactions, exists as a superfamily of enzymes. Genetic polymorphism has been described for 6 of the 16 functional human UGT genes characterised to date, namely UGT 1A1, 1A6, 1A7, 2B4, 2B7 and 2B15. Since glucuronidation is an essential pathway for the elimination of a myriad of xenobiotics and endogenous compounds, genetic polymorphism of UGT is potentially of toxicological and physiological importance… CONTINUE READING

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