Genetic polymorphisms of alcohol and aldehyde dehydrogenases, and drinking, smoking and diet in Japanese men with oral and pharyngeal squamous cell carcinoma.

@article{Asakage2007GeneticPO,
  title={Genetic polymorphisms of alcohol and aldehyde dehydrogenases, and drinking, smoking and diet in Japanese men with oral and pharyngeal squamous cell carcinoma.},
  author={Takahiro Asakage and Akira Yokoyama and Tatsumasa Haneda and Mitsuo Yamazaki and Manabu Muto and Tetsuji Yokoyama and Hoichi Kato and Hiroyasu Igaki and Toshimasa Tsujinaka and Yoshiya Kumagai and Masako Yokoyama and Tai Omori and Hiroshi Watanabe},
  journal={Carcinogenesis},
  year={2007},
  volume={28 4},
  pages={865-74}
}
The genetic polymorphisms of aldehyde dehydrogenase-2 (ALDH2), alcohol dehydrogenase-1B (ADH1B, previously called ADH2), and ADH1C (previously called ADH3) affect the metabolism of alcohol. The inactive ALDH2 encoded by ALDH2*1/*2 and the less-active ADH1B encoded by ADH1B*1/*1 increase the risk of esophageal squamous cell carcinoma in East Asian drinkers. This case-control study involved 96 Japanese men with oral and pharyngeal squamous cell carcinoma (hypopharyngeal cancer in 43 patients and… CONTINUE READING