Genetic polymorphisms of NAT2, CYP2E1 and GST enzymes and the occurrence of antituberculosis drug-induced hepatitis in Brazilian TB patients.

@article{Teixeira2011GeneticPO,
  title={Genetic polymorphisms of NAT2, CYP2E1 and GST enzymes and the occurrence of antituberculosis drug-induced hepatitis in Brazilian TB patients.},
  author={Raquel Teixeira and Renata Gomes Morato and Pedro Hern{\'a}n Cabello and Ligia Mayumi Kitada Muniz and Adriana da Silva Rezende Moreira and Afr{\^a}nio Lineu Kritski and Fernanda Carvalho de Queiroz Mello and Philip Noel Suffys and Antonio Bas{\'i}lio de Miranda and Adalberto Rezende Santos},
  journal={Memorias do Instituto Oswaldo Cruz},
  year={2011},
  volume={106 6},
  pages={716-24}
}
Isoniazid (INH), one of the most important drugs used in antituberculosis (anti-TB) treatment, is also the major drug involved in hepatotoxicity. Differences in INH-induced toxicity have been attributed to genetic variability at several loci, such as NAT2, CYP2E1, GSTM1 and GSTT1, that code for drug-metabolising enzymes. Our goal was to examine the polymorphisms in these enzymes as susceptibility factors to anti-TB drug-induced hepatitis in Brazilian individuals. In a case-control design, 167… CONTINUE READING

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Thoracic Society) Hepatotoxicity of Antituberculosis Therapy

  • JJ Saukkonen, DL Cohn, +11 authors American ATS
  • Subcommittee
  • 2006
Highly Influential
4 Excerpts

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