Genetic polymorphisms of IL-23R and IL-17A and novel insights into their associations with inflammatory bowel disease.

@article{Kim2011GeneticPO,
  title={Genetic polymorphisms of IL-23R and IL-17A and novel insights into their associations with inflammatory bowel disease.},
  author={Seung Won Kim and Eun Soo Kim and Chang Mo Moon and Jae Jun Park and Tae Il Kim and Won Ho Kim and Jae Hee Cheon},
  journal={Gut},
  year={2011},
  volume={60 11},
  pages={1527-36}
}
BACKGROUND AND AIMS To identify the associations of genetic and epigenetic variations in IL-23R and IL-17A with inflammatory bowel diseases (IBD). METHODS The promoter and exon regions of IL-23R and IL-17A were analysed in 727 subjects (201 Crohn's disease, 268 ulcerative colitis and 258 healthy controls) using DNA sequencing and denaturing high performance liquid chromatography. Transcription factor binding affinity, IL-17A mRNA expression and methylation of the IL-17A promoter were… CONTINUE READING
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Contribution of IL 23 R but not ATG 16 L 1 to Crohn ’ s disease susceptibility in Koreans

RL Roberts, RB Gearry, JE Hollis-Moffatt
Inflamm Bowel Dis • 2009

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