Genetic polymorphisms of CYP2D6 in Chinese mainland.

  title={Genetic polymorphisms of CYP2D6 in Chinese mainland.},
  author={Ling Fen Ji and Shixiu Pan and Jianmin Wu and Jacqueline Marti-Jaun and Martin Hersberger},
  journal={Chinese medical journal},
  volume={115 12},
OBJECTIVE To observe the significant differences in the frequencies of the cytochrome P450 2D6 (CYP2D6) alleles in Chinese popoulations. METHODS Tetra-primer polymerase chain reaction (PCR), allele specific amplification (ASA) PCR and multiplex long PCR were developed to detect the CYP2D6 alleles * 2, * 3, * 4, * 5, * 6, * 8, * 10 and * 14 in 223 subjects from Chinese mainland. RESULTS The CYP2D6 * 5 allele was the most frequent poor metabolizer (PM) allele in Chinese (7.2%), followed by… CONTINUE READING

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