Genetic polymorphisms of CYP2C8 in Japanese population.

  title={Genetic polymorphisms of CYP2C8 in Japanese population.},
  author={Miki Nakajima and Yuto Fujiki and Kumiko Noda and Hiroki Ohtsuka and Hisashi Ohkuni and Satoru Kyo and Masaki Inoue and Yukio Kuroiwa and Tsuyoshi Yokoi},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={31 6},
CYP2C8 plays important roles in metabolizing therapeutic drugs and endogenous compounds. Although genetic polymorphisms of CYP2C8 were reported, there is little information on CYP2C8 polymorphisms in the Japanese population. In the present study, we screened for previously described polymorphisms in the coding region of this gene using polymerase chain reaction (PCR)-restriction fragment length polymorphism or allele specific-PCR analyses. Eleven polymorphisms of CYP2C8*2 (I269F), CYP2C8*3… CONTINUE READING
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