Genetic polymorphisms of CYP2C8, CYP2C9 and CYP2C19 in Ecuadorian Mestizo and Spaniard populations: a comparative study

@article{Vicente2013GeneticPO,
  title={Genetic polymorphisms of CYP2C8, CYP2C9 and CYP2C19 in Ecuadorian Mestizo and Spaniard populations: a comparative study},
  author={Jorge Garc{\'i}a Vicente and Fabricio Gonz{\'a}lez-Andrade and Antonia Soriano and Ana J Fanlo and Begona Martinez-Jarreta and Blanca Sinu{\'e}s},
  journal={Molecular Biology Reports},
  year={2013},
  volume={41},
  pages={1267-1272}
}
This study was designed to investigate the potential differences between Spaniards and Ecuadorian Mestizo people regarding CYP2C8, CYP2C9, and CYP2C19 genetic polymorphisms. DNA from 282 Spaniard and 297 Ecuadorian subjects were analyzed by either a previously reported pyrosequencing method (CY2C8*3, CYP2C9*2, CYP2C9*3, CYP2C19*2 and CYP2C19*3) or a nested PCR technique (CYP2C19*17). Whereas CYP2C19*17 allele distribution was higher in Ecuadorians than in Spaniards (P < 0.001) and the frequency… CONTINUE READING

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References

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Interethnic and intraethnic variability of CYP2C8 and CYP2C9 polymorphisms in healthy individuals

  • E Garcı́a-Martı́n, C Martı́nez, JM Ladero, JA Agúndez
  • Mol Diagn Ther
  • 2006
Highly Influential
4 Excerpts

Interindividual variability in ibuprofen pharmacokinetics is related to interaction of cytochrome P450 2C8 and 2C9 amino acid polymorphisms

  • E Garcı́a-Martı́n, C Martı́nez, B Tabarés, J Frı́as, JA Agúndez
  • Clin Pharmacol Ther
  • 2004
Highly Influential
14 Excerpts

CYP 2 C 9 allele frequency differences between populations of Mexican - Mestizo , Mexican - Tepehuano , and Spaniards

  • A Roco, L Quiñones, +7 authors N Varela
  • 2012

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