Genetic polymorphisms of 17 β-hydroxysteroid dehydrogenase 3 and the risk of hypospadias.

@article{Sata2010GeneticPO,
  title={Genetic polymorphisms of 17 β-hydroxysteroid dehydrogenase 3 and the risk of hypospadias.},
  author={Fumihiro Sata and Norie Kurahashi and Susumu Ban and Kimihiko Moriya and Kazuyuki Tanaka and Mayumi Ishizuka and Hiroyuki Nakao and Yuichiro Yahata and Hirohisa Imai and Hidehiro Kakizaki and Katsuya Nonomura and Reiko Kishi},
  journal={The journal of sexual medicine},
  year={2010},
  volume={7 8},
  pages={2729-38}
}
INTRODUCTION Hypospadias is a common congenital anomaly caused by incomplete fusion of urethral folds. Development of the urethra and external genital system in the male fetus is an androgen-dependent process. In this regard, enzymes 17 β-hydroxysteroid dehydrogenase type 3 (17 β HSD3, encoded by HSD17B3) and steroid 5 α-reductase type 2 (encoded by SRD5A2) play crucial roles. AIM To investigate the possible associations between common polymorphisms in HSD17B3 as well as well-known V89L… CONTINUE READING
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