Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 (UGT1A1) and risk of breast cancer

@article{Adegoke2004GeneticPI,
  title={Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 (UGT1A1) and risk of breast cancer},
  author={Olufemi J. Adegoke and Xiao-Ou Shu and Yu-tang Gao and Qiuyin Cai and Joan P. Breyer and Jeffrey R. Smith and Wei Zheng},
  journal={Breast Cancer Research and Treatment},
  year={2004},
  volume={85},
  pages={239-245}
}
Uridine diphospho-glucuronosyltransferase 1A1 (UGT1A1) is involved in catalyzing estrogen, the hormone that plays a central role in the etiology of breast cancer. A common polymorphism [A(TA)6TAA (allele *1) to A(TA)7TAA change (allele *28)] in the TATA-box of the promoter region of the UGT1A1 gene has been reported to be associated with a reduced transcription of this gene. We investigated the association of this polymorphism with the risk of breast cancer among 1047 breast cancer cases and… CONTINUE READING