Genetic polymorphisms in transforming growth factor beta-1 (TGFB1) and childhood asthma and atopy

@article{Li2007GeneticPI,
  title={Genetic polymorphisms in transforming growth factor beta-1 (TGFB1) and childhood asthma and atopy},
  author={Huiling Li and Isabelle Romieu and Hao Wu and Juan Jos{\'e} Luis Sienra-Monge and Matiana Ram{\'i}rez-Aguilar and Blanca Estela del R{\'i}o-Navarro and Irma Del Carmen Lara-Sanchez and Emily O. Kistner and H{\aa}kon K Gjessing and Stephanie J London},
  journal={Human Genetics},
  year={2007},
  volume={121},
  pages={529-538}
}
Transforming growth factor beta-1 (TGFB1) may influence asthma by modulating allergic airway inflammation and airway remodeling. The role of single nucleotide polymorphisms (SNPs) of TGFB1 in asthma remains inconclusive. We examined TGFB1 SNPs in relation to asthma risk and degree of atopy among 546 case-parent triads, consisting of asthmatics aged 4–17 years and their parents in Mexico City. Atopy to 24 aeroallergens was determined by skin prick tests. We genotyped five TGFB1 SNPs, including… CONTINUE READING

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