Genetic polymorphisms in the thioredoxin 2 (TXN2) gene and risk for spina bifida.

Abstract

TXN2 encodes human thioredoxin 2, a small redox protein important in cellular antioxidant defenses, as well as in the regulation of apoptosis. Txn2 knockout mice fail to complete neural tube closure by E10.5 and die in utero. We hypothesized that genetic variation in human TXN2 gene may alter the function of the encoded protein in a manner associated with… (More)
DOI: 10.1002/ajmg.a.32589

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@article{Wen2009GeneticPI, title={Genetic polymorphisms in the thioredoxin 2 (TXN2) gene and risk for spina bifida.}, author={Shu Wen and Wei Dang Lu and Huiping Zhu and Wei Yang and Gary M Shaw and Edward J. Lammer and A K M Mominul Islam and Richard H. Finnell}, journal={American journal of medical genetics. Part A}, year={2009}, volume={149A 2}, pages={155-60} }