Genetic polymorphisms in the osteopontin promoter increases the risk of distance metastasis and death in Chinese patients with gastric cancer

@inproceedings{Zhao2012GeneticPI,
  title={Genetic polymorphisms in the osteopontin promoter increases the risk of distance metastasis and death in Chinese patients with gastric cancer},
  author={Fujun Zhao and Xiaoyi Chen and Tingting Meng and Bo Hao and Zhihong Zhang and Guoxin Zhang},
  booktitle={BMC Cancer},
  year={2012}
}
BackgroundIn vitro and in vivo studies have suggested that osteopontin (OPN) is associated with many types of cancers. However, no studies have reported the incidence of OPN polymorphisms and the risk of gastric cancer. The aim of this study was to investigate the association between OPN polymorphisms and gastric cancer in a Chinese patient population.MethodsThree genetic variants in the OPN promoter were genotyped using direct sequencing in 200 gastric cancer patients and 200 gender- and age… CONTINUE READING

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