Genetic polymorphisms in the human selenoprotein P gene determine the response of selenoprotein markers to selenium supplementation in a gender‐specific manner (the SELGEN study)

@article{Meplan2007GeneticPI,
  title={Genetic polymorphisms in the human selenoprotein P gene determine the response of selenoprotein markers to selenium supplementation in a gender‐specific manner (the SELGEN study)},
  author={Catherine Méplan and Lynne K. Crosley and Fergus Nicol and Geoffrey J. Beckett and Alexander F. Howie and Kristina E. Hill and Graham W. Horgan and John Cummings Mathers and John R. Arthur and John E. Hesketh},
  journal={The FASEB Journal},
  year={2007},
  volume={21},
  pages={3063 - 3074}
}
Selenium (Se), a micronutrient essential for human health, is incorporated into at least 25 selenoproteins including selenoprotein P (SePP)′ which transports Se within the body. This research identified two single nucleotide polymorphisms (SNPs) in the SePP gene, one in the coding region (position 24731, causing an Ala to Thr change) and one in the 3′untranslated region (position 25191). Their frequency was similar in Caucasian, Chinese, and South Asian populations. Prospectively geno‐typed… 
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Genetic polymorphism in selenoprotein P modifies the response to selenium-rich foods on blood levels of selenium and selenoprotein P in a randomized dietary intervention study in Danes

This study indicates that genetically determined variation in SELENOP leads to different responses in expression of selenoproteins following consumption of seenium-rich foods.

Functional effects of a common single-nucleotide polymorphism (GPX4c718t) in the glutathione peroxidase 4 gene: interaction with sex.

The GPX4c718t SNP both alters protein binding to the 3'UTR in vitro and influences the concentration of lymphocyte GPx4 and other selenoproteins in vivo and, at low selenium intake, the SNP thus may influence susceptibility to disease.

Relative abundance of selenoprotein P isoforms in human plasma depends on genotype, se intake, and cancer status.

It is concluded that functional polymorphisms in the SEPP-1 gene influence the proportion of SePP isoforms in plasma and an elevated proportion of the 60-kDa isoform of Se PP may increase selenoprotein synthesis and reduce colorectal cancer risk.

Genetic variants in selenoprotein P plasma 1 gene (SEPP1) are associated with fasting insulin and first phase insulin response in Hispanics.

Genetic polymorphisms in selenoprotein P gene affect colorectal, prostate and breast cancer risk

Two single nucleotide polymorphisms (SNP) that affect SePP plasma isoform pattern and expression of other selenoproteins were identified in the SEPP1 gene, suggesting that genotype for these twoSEPP1 variants affects cancer risk.

Genetic variants in selenoprotein genes modulate biomarkers of selenium status in response to Brazil nut supplementation (the SU.BRA.NUT study).

Genetically determined variations of selenoprotein P are associated with antioxidant, muscular, and lipid biomarkers in response to Brazil nut consumption by patients using statins

SNPs in SELENOP could be associated with interindividual differences in Se homeostasis after Brazil nut consumption, emphasising the involvement of genetic variability in response to Se consumption towards health maintenance and disease prevention.

Selenoprotein genes variants may modify the association between serum selenium and oral cancer risk.

It is suggested that serum Se levels may be significantly associated with oral cancer risk, yet the association may be modified by the effects of selenoprotein genes variants.

Influence of Genetic Variations in Selenoprotein Genes on the Pattern of Gene Expression after Supplementation with Brazil Nuts

Genetic variations in selenoprotein genes modulated both GPX1 and SELENOP selenobrotein gene expression and global gene expression in response to Brazil nut supplementation.

Optimization of selenoprotein P and other plasma selenium biomarkers for the assessment of the selenium nutritional requirement: a placebo-controlled, double-blind study of selenomethionine supplementation in selenium-deficient Chinese subjects.

The present results indicate that SEPP1 concentration is the best plasma biomarker studied for assessing optimal expression of all selenoproteins, because its optimization required a larger intake of selenium than did GPX activity.
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References

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Selenium in the form of selenomethionine is better absorbed than selenite, and plasma selenium concentration is useful in monitoring compliance and safety ofselenium supplementation as selenometrichionines but not as seenite.

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The results suggest that Se-P from liver provides selenium to several tissues, especially testis and brain, and indicate that transport forms of seenium other than Se-p exist because selenia levels of all tissues except testis responded to increases of dietary selenIUM in Sepp −/− mice.

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The importance of selenium to human health