Genetic polymorphisms in the UDP-glucuronosyltransferase UGT1A7 gene in patients with acute liver failure after kava-kava consumption

@article{Aghdassi2015GeneticPI,
  title={Genetic polymorphisms in the UDP-glucuronosyltransferase UGT1A7 gene in patients with acute liver failure after kava-kava consumption},
  author={Ali A Aghdassi and Matthias Kraft and Wolfram Domschke and Markus M. Lerch and Frank Ulrich Weiss},
  journal={Archives of Toxicology},
  year={2015},
  volume={89},
  pages={2173-2174}
}
are important mediators for the inactivation and excretion of various endogenous and exogenous compounds because of their involvement in glucuronide conjugate formation. Polymorphisms of the UGT1A7 gene were found to be associated with various liver diseases including an association of hepatocellular carcinoma with the low detoxification activity of the UGT1A7*3 isoform and UGT1A7 variations with liver cirrhosis (Vogel et al. 2001). In our patients with fulminant liver failure, the ingestion of… CONTINUE READING

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