Genetic polymorphisms in the Fas and FasL genes are associated with epithelial ovarian cancer risk and clinical outcomes.

@article{Li2013GeneticPI,
  title={Genetic polymorphisms in the Fas and FasL genes are associated with epithelial ovarian cancer risk and clinical outcomes.},
  author={Yan Li and Ya-li Hao and Shan Kang and Rong-miao Zhou and Na Wang and Bing-li Qi},
  journal={Gynecologic oncology},
  year={2013},
  volume={128 3},
  pages={584-9}
}
AIM In this study, we evaluated whether functional polymorphisms within the Fas and FasL genes were associated with the risk of developing epithelial ovarian cancer (EOC) and survival of patients with EOC. METHODS A case-control study was performed in 342 EOC patients and 344 control women. The genotypes of three promoter region polymorphisms (Fas -1377G/A, -670A/G and FasL -844T/C) were determined using ligase detection reaction-polymerase chain reaction (LDR-PCR). The clinical outcomes in… CONTINUE READING
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