Genetic polymorphisms in microsomal epoxide hydrolase and susceptibility to adult acute myeloid leukaemia with defined cytogenetic abnormalities.

@article{Lebailly2002GeneticPI,
  title={Genetic polymorphisms in microsomal epoxide hydrolase and susceptibility to adult acute myeloid leukaemia with defined cytogenetic abnormalities.},
  author={Pierre Lebailly and Eleanor V. Willett and Anthony V Moorman and Eve Roman and Ray Cartwright and Gareth J Morgan and Christopher Paul Wild},
  journal={British journal of haematology},
  year={2002},
  volume={116 3},
  pages={587-94}
}
Acute myeloid leukaemia (AML) cases with different chromosomal abnormalities may reflect different aetiologies. Benzene exposure, from a number of sources including smoking, is one risk factor for AML. Individual susceptibility to benzene may depend on differences in expression of metabolizing enzymes. We tested the hypothesis that smoking as well as genetic polymorphisms in the microsomal epoxide hydrolase gene (HYL1), an enzyme involved in benzene metabolism, could be risk factors for AML… CONTINUE READING
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