Genetic polymorphisms in heterocyclic amine metabolism and risk of colorectal adenomas.

@article{Ishibe2002GeneticPI,
  title={Genetic polymorphisms in heterocyclic amine metabolism and risk of colorectal adenomas.},
  author={Naoko Ishibe and Rashmi Sinha and David W Hein and Martin Kulldorff and Paul Strickland and Adrian J. Fretland and Wong-Ho Chow and Fred F. Kadlubar and Nicholas P. Lang and Nathaniel Rothman},
  journal={Pharmacogenetics},
  year={2002},
  volume={12 2},
  pages={145-50}
}
High red meat intake has been linked with an increased risk of colorectal cancer and adenomas. During high temperature cooking of red meats, heterocyclic amines (HCAs) are generated; however, to be carcinogenic, they must be metabolized by enzymes including cytochrome P450 1A2 (CYP1A2) and N-acetyltransferase 1 (NAT1) and/or N-acetyltransferase 2 (NAT2). We have conducted a clinic-based case-control study of colorectal adenomas that focused on assessment of exposure to HCAs (estimated by use of… CONTINUE READING
36 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

Similar Papers

Loading similar papers…