Genetic polymorphisms in dopaminergic system and treatment-resistant schizophrenia.

  title={Genetic polymorphisms in dopaminergic system and treatment-resistant schizophrenia.},
  author={Tea Terzi{\vc} and Matej Kastelic and Vita Dol{\vz}an and Blanka Kores Plesni{\vc}ar},
  journal={Psychiatria Danubina},
  volume={28 2},
BACKGROUND Dopaminergic system plays an important role in antipsychotic response. Functional single nucleotide polymorphisms (SNPs) can change dopamine receptor expression or dopamine disposition and thus influence response to antipsychotic treatment. SUBJECTS AND METHODS 138 schizophrenia patients were stratified in the treatment-resistant and treatment-responsive group. Control group consisted of 94 healthy blood donors. All subjects were genotyped for the following SNPs: DRD1 (rs4532… CONTINUE READING
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