Genetic polymorphisms in dilated cardiomyopathy.

@article{Stambader2010GeneticPI,
  title={Genetic polymorphisms in dilated cardiomyopathy.},
  author={Johann Daniel Stambader and Livia Dorn and Gregor Mikuz and Consolato M. Sergi},
  journal={Frontiers in bioscience},
  year={2010},
  volume={2},
  pages={
          653-76
        }
}
Dilated cardiomypathies (DCM) are characterized by dilatation and pump dysfunction of the heart. DCM has an incidence of 6/100.000 people a year contributing to a considerable number of cases of heart failure. Although etiology and pathogenesis are known to be multifactorial, they remain mostly unidentified. Recent research identified patients affected with DCM with altered gene products. These alterations can roughly be grouped into causative genes, mostly coding for cytoskeletal proteins… 
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The present review article will focus on the role of CMR in the evaluation of present condition, analysing respective strengths and limitations in the light of current literature and technological developments.
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Different genetic mechanisms that have been shown to underlie a variety of cardiovascular diseases are discussed and different genetic regions involved in the pathogenesis of congenital heart diseases are reviewed.
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Evidence is provided that both rs6503691 T allele and CT/TT genotypes, but not rs4796793 C/G in the 5′ region of STAT3, are associated with a significantly increased risk of DCM, indicating that common genetic polymorphism in STATs is associated with DCM.
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