Genetic polymorphisms in MMP 2, 9 and 3 genes modify lung cancer risk and survival

@inproceedings{GonzlezArriaga2011GeneticPI,
  title={Genetic polymorphisms in MMP 2, 9 and 3 genes modify lung cancer risk and survival},
  author={Patricia Gonz{\'a}lez-Arriaga and Teresa Pascual and Arturo Garc{\'i}a-Alvarez and Ana Fernandez-Somoano and Mar{\'i}a Felicitas L{\'o}pez-Cima and Adonina Tard{\'o}n},
  booktitle={BMC Cancer},
  year={2011}
}
Matrix metalloproteases (MMPs) are proteolytic enzymes that contribute to all stages of tumour progression, including the later stages of invasion and metastasis. Genetic variants in the MMP genes may influence the biological function of these enzymes and change their role in carcinogenesis and progression. We have investigated the association between the -735 C/T, the -1171 5A/6A, and the -1562 C/T polymorphisms in the MMP2, MMP3 and MMP9 genes, respectively, and the risk and survival of lung… CONTINUE READING