Genetic polymorphisms in APE1 are associated with renal cell carcinoma risk in a Chinese population.

@article{Cao2011GeneticPI,
  title={Genetic polymorphisms in APE1 are associated with renal cell carcinoma risk in a Chinese population.},
  author={Qiang Cao and Chao Qin and Xiaoxin Meng and Xiaobing Ju and Qi Han Ding and Meilin Wang and Jian Ping Zhu and Wei Wang and P. Y. Li and Jiawei Chen and Zhengdong Zhang and Changjun Yin},
  journal={Molecular carcinogenesis},
  year={2011},
  volume={50 11},
  pages={863-70}
}
Apurinic/apyrimidinic endonuclease 1 (APE1) is a DNA repair protein, which plays important roles in the base excision repair (BER) pathway. Genetic variations of APE1 have been shown to influence an individual's susceptibility to carcinogenesis. We hypothesized the genetic polymorphisms of APE1 are associated with the risk of renal cell carcinoma (RCC). In a case-control study of 612 RCC patients and 632 age and sex matched healthy controls, we genotyped two APE1 functional polymorphisms (-656… CONTINUE READING