Genetic polymorphism of the tissue inhibitor of metalloproteinase-1 is associated with an increased risk of endometrial cancer.

@article{Yi2009GeneticPO,
  title={Genetic polymorphism of the tissue inhibitor of metalloproteinase-1 is associated with an increased risk of endometrial cancer.},
  author={Yu-Chiao Yi and M K Chen and Ling-Yun Chen and Esther Shih-Chu Ho and T S Ying and P Wang and Shun-Fa Yang},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2009},
  volume={409 1-2},
  pages={127-31}
}
BACKGROUND Tissue inhibitors of metalloproteinases (TIMPs) are a family of multifunctional proteins known to possess a broad range of biological activities involved in tumorgenesis and mRNA expression of TIMP family members has been shown to be upregulated in numerous cancers and correlates with clinical outcomes. We investigated the association of TIMP-1 and TIMP-2 gene polymorphism with risk of endometrial cancer. METHODS In the present case-control study, we enrolled a total of 118… CONTINUE READING