Genetic polymorphism of the second component of human complement (C2)

  title={Genetic polymorphism of the second component of human complement (C2)},
  author={Bj{\o}rnar Olaisen and Per Teisberg and Tobias Gedde-Dahl and Erik Thorsby},
  journal={Human Genetics},
Proteins were separated by prolonged isoelectric focusing in polyacrylamide gels, whereupon C2 bands were detected by a specific hemolytic assay. This was performed by treating the gel with iodine to increase C2 activity, and then developing C2 bands with an agarose gel overlay containing sensitized sheep cells and diluted human serum as a complement source deficient in functional C2. The gene frequencies observed in a material of 122 unrelated adults were: C21:0.97 and C22:0.03. C2 linkage… CONTINUE READING

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