Genetic polymorphism of murine tissue plasminogen activator associated with antiphospholipid syndrome

@article{Shirai1999GeneticPO,
  title={Genetic polymorphism of murine tissue plasminogen activator associated with antiphospholipid syndrome},
  author={Junsuke Shirai and A. Ida and Yi Jiang and Reiko Sanokawa-Akakura and Yutaka Miura and Kang Hua Yan and Yoshitomo Hamano and S. Hirose and Toshikazu Shirai},
  journal={Genes and Immunity},
  year={1999},
  volume={1},
  pages={130-136}
}
In a subset of patients with systemic lupus erythematosus (SLE), antiphospholipid syndrome characterized by thrombocytopenia, thrombosis, recurrent abortion and antiphospholipid antibodies develops. Male (NZW × BXSB) F1 mice are widely used as a model for SLE-associated antiphospholipid syndrome. Our earlier genetic studies showed that one susceptibility allele for thrombocytopenia and associated IgG platelet-binding autoantibodies in male (NZW × BXSB) F1 mice was linked to the BXSB-type… CONTINUE READING
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