Genetic polymorphism of 5,10-methylenetetrahydrofolate increases risk of myocardial infarction and is correlated to elevated levels of homocysteine in the Japanese general population.

@article{Nakai2000GeneticPO,
  title={Genetic polymorphism of 5,10-methylenetetrahydrofolate increases risk of myocardial infarction and is correlated to elevated levels of homocysteine in the Japanese general population.},
  author={Keiko Nakai and Tetsuya Fusazaki and Toshiki Suzuki and Masaki Ohsawa and Naonori Ogiu and Junya Kamata and Kohei Kawazoe and Chuichi Itoh and Morifumi Yanagisawa and Takaeshi Ishida and Katsuhiko Hiramori},
  journal={Coronary artery disease},
  year={2000},
  volume={11 1},
  pages={
          47-51
        }
}
BACKGROUND Hyperhomocysteinemia, an independent and graded risk factor for coronary artery disease, can result from both environmental and hereditary factors. C677T mutation of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene [alanine/valine (A/V) polymorphism], one of the key enzymes involved in catalyzing the remethylation of homocysteine, has recently been reported. OBJECTIVE To evaluate the incidence of the MTHFR genotypes and their significance in determining the risk for… CONTINUE READING
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