Genetic polymorphism of human CYP2E1: characterization of two variant alleles.

@article{Hu1997GeneticPO,
  title={Genetic polymorphism of human CYP2E1: characterization of two variant alleles.},
  author={Yun Hu and Mikael Oscarson and Inger Johansson and Q. Y. Yue and Marja Liisa Dahl and M. -D. Tabone and S Arinc{\`o} and Emanuele Albano and Magnus Ingelman-Sundberg},
  journal={Molecular pharmacology},
  year={1997},
  volume={51 3},
  pages={370-6}
}
Ethanol-inducible CYP2E1 is an enzyme of major toxicological interest because it metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. CYP2E1 has also been implicated in alcohol liver disease because of its contribution to oxidative stress. Previously, polymorphic alleles with mutations in introns and in the 5'-flanking regulatory… CONTINUE READING