Genetic polymorphism of glutathione S-transferase genes (GSTM1, GSTT1 and GSTP1) and susceptibility to prostate cancer in Northern India.

@article{Srivastava2005GeneticPO,
  title={Genetic polymorphism of glutathione S-transferase genes (GSTM1, GSTT1 and GSTP1) and susceptibility to prostate cancer in Northern India.},
  author={Daya Shankar Lal Srivastava and Anil Mandhani and Balraj Mittal and Rama Devi Mittal},
  journal={BJU international},
  year={2005},
  volume={95 1},
  pages={170-3}
}
OBJECTIVE To examine the association of glutathione-S-transferase (GST) gene polymorphisms in patients with sporadic prostate cancer, in a North Indian population, as GSTs are active in detoxifying a wide variety of endogenous or exogenous carcinogens, and genetic polymorphisms of GSTM1, GSTT1 and GSTP1 have been assessed to evaluate the relative risk of various cancers. PATIENTS AND METHODS We assessed 127 patients with prostate cancer and 144 age-matched controls, all from North India. The… CONTINUE READING

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