Genetic polymorphism of debrisoquine (CYP2D6) and proguanil (CYP2C19) in South Pacific Polynesian populations

@article{Wanwimolruk1998GeneticPO,
  title={Genetic polymorphism of debrisoquine (CYP2D6) and proguanil (CYP2C19) in South Pacific Polynesian populations},
  author={Sompon Wanwimolruk and Sadhna Bhawan and Philippe Coville and Stephen C W Chalcroft},
  journal={European Journal of Clinical Pharmacology},
  year={1998},
  volume={54},
  pages={431-435}
}
Objective: Genetic oxidation polymorphisms of debrisoquine (CYP2D6) and proguanil (CYP2C19) were studied in unrelated healthy South Pacific Polynesian volunteers recruited in the South Island of New Zealand. Methods: Phenotyping for CYP2D6 and CYP2C19 activities was determined using debrisoquine and proguanil, respectively, as probe drugs by measuring the urinary metabolic ratio of parent drug and its␣metabolite. Results: Of 100 Polynesian subjects phenotyped, the metabolic ratio of… CONTINUE READING

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