Genetic polymorphism of cytochrome P-4502E1 and mitochondrial aldehyde dehydrogenase in a Korean population.

@article{Lee1997GeneticPO,
  title={Genetic polymorphism of cytochrome P-4502E1 and mitochondrial aldehyde dehydrogenase in a Korean population.},
  author={Kyuhyun Lee and Byung-Kwan Kwak and Jeffrey H. Kim and Seung Kwan Yoo and Seungshic Yum and Hack Seong Jeong},
  journal={Alcoholism, clinical and experimental research},
  year={1997},
  volume={21 6},
  pages={953-6}
}
Mitochondrial aldehyde dehydrogenase (ALDH2) is mainly responsible for the oxidation of acetaldehyde generated during alcohol oxidation in vivo. Cytochrome P-4502E1 (CYP2E1), a liver microsomal enzyme, also metabolizes acetaldehyde and ethanol. Genetic polymorphism of ALDH2 and CYP2E1 was investigated among 481 Korean adults. A new restriction fragment… CONTINUE READING