Genetic polymorphism of cytochrome P 450 2C9 in diphenylhydantoin-induced cutaneous adverse drug reactions

Abstract

Apart from allergic mechanisms, a lack or mutation of metabolic enzymes may cause adverse drug reactions. Patch testing has rarely been useful in cutaneous adverse drug reactions (CADRs) induced by diphenylhydantoin (DPH). Genetic polymorphisms leading to altered metabolic processes of cytochrome P 450 (CYP) 2C9, a main metabolic enzyme for DPH, may be the… (More)
DOI: 10.1007/s00228-004-0753-0

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@article{Lee2004GeneticPO, title={Genetic polymorphism of cytochrome P 450 2C9 in diphenylhydantoin-induced cutaneous adverse drug reactions}, author={A. B. Lee and Min-Jung Kim and W D Chey and Jun Choi and Byung-Gun Kim}, journal={European Journal of Clinical Pharmacology}, year={2004}, volume={60}, pages={155-159} }