Genetic polymorphism of cynomolgus and rhesus macaque CYP2C9.

Abstract

Cynomolgus and rhesus macaques are non-human primate species widely used in drug metabolism studies. Cynomolgus CYP2C9 (formerly known as CYP2C43) is predominantly expressed in liver and encodes a drug-metabolizing enzyme that metabolizes human CYP2C substrates such as S-mephenytoin and progesterone. In addition, cynomolgus CYP2C9 also metabolizes caffeine… (More)
DOI: 10.1016/j.dmpk.2014.10.002

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