Genetic polymorphism of alcohol dehydrogenase in europeans: the ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1.

@article{Borrs2000GeneticPO,
  title={Genetic polymorphism of alcohol dehydrogenase in europeans: the ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1.},
  author={Eva Borr{\'a}s and Christiane Coutelle and Antoni Rosell and F Fern{\'a}ndez-Muix{\'i} and Montserrat Broch and Bernat Crosas and Lars Hjelmqvist and Alfons Lorenzo and Carmen Villaverde Gutierrez and Mauro Santos and Małgorzata Szczepanek and Markus Heilig and Paolina Quattrocchi and Jordi Farr{\'e}s and F. Javier S{\'a}nchez Vidal and Crist{\'o}bal Richart and Tomasz H. Mach and J{\'o}zef Bogdal and Hans J{\"o}rnvall and Helmut Karl Seitz and Patrice Couzigou and Xavier Par{\'e}s},
  journal={Hepatology},
  year={2000},
  volume={31 4},
  pages={984-9}
}
Polymorphism at the ADH2 and ADH3 loci of alcohol dehydrogenase (ADH) has been shown to have an effect on the predisposition to alcoholism in Asian individuals. However, the results are not conclusive for white individuals. We have analyzed the ADH genotype of 876 white individuals from Spain (n = 251), France (n = 160), Germany (n = 184), Sweden (n = 88), and Poland (n = 193). Peripheral blood samples from healthy controls and groups of patients with viral cirrhosis and alcohol-induced… CONTINUE READING
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Interaction between the functional polymorphisms of the alcohol metabolism genes in protection against alcoholism

  • Chen C-C, Lu R-B, +4 authors Yin S-J
  • Am J Hum Genet
  • 1999

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