Genetic polymorphism of KIR2DL4 in the Polish population.

@article{Nowak2015GeneticPO,
  title={Genetic polymorphism of KIR2DL4 in the Polish population.},
  author={Izabela Nowak and Ewa Barcz and Edyta Majorczyk and Alexander Malinowski and Jacek Radosław Wilczyński and Marisa Banasik and Hanna Motak-Pochrzęst and Piotr Kuśnierczyk},
  journal={Tissue antigens},
  year={2015},
  volume={85 6},
  pages={450-7}
}
The KIR2DL4 gene is characterized by alleles with either 9 or 10 consecutive adenines in exon 7, which encodes the transmembrane domain. The 9A variant produces either a protein with a truncated cytoplasmic tail or one lacking the transmembrane region. This causes a lack of KIR2DL4 expression. In contrast, 10A alleles encode receptors that may be expressed at the cell surface. We tested 438 healthy individuals for polymorphism of the KIR2DL4 gene. KIR2DL4 9A/10A alleles were distinguished by… CONTINUE READING
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